Below are studies done on the Collagen Peptides used in Skinergy

Collagen Peptides & Skin Protection from Environmental Damage

Published in Journal of Agricultural and Food Chemistry, 2014.

Study Type: Randomized, double-blind, placebo-controlled human trial

This clinical study examined how daily collagen peptide intake affects the skin’s response to ultraviolet (UV) exposure, one of the primary drivers of premature aging.

Key Findings:

  • Collagen peptide supplementation reduced UV-induced skin damage (erythema)
  • Effects were statistically significant in individuals over age 30
  • No adverse effects were reported over the study period

What This Means:

Collagen peptides don’t just support skin from within, they may help protect it from external stressors, like sun exposure, that contribute to visible aging.

Effects of Collagen Peptide Supplementation on Skin Aging

Published in Journal of Cosmetic Dermatology, 2017.

Study Type: Randomized, double-blind, placebo-controlled human trial

This clinical study evaluated the effects of daily collagen peptide supplementation on visible signs of skin aging in healthy adult women.

Key Findings:

  • Daily collagen peptide intake for 8 weeks resulted in a statistically significant reduction in wrinkle depth compared to placebo
  • Improvements were measured using standardized imaging technology (VISIA system)
  • Participants showed measurable improvements in:


    Skin texture
    Skin smoothness
    Overall wrinkle appearance


  • The magnitude of improvement corresponded to an estimated
    ~3.7-year reduction in apparent skin aging
  • No adverse effects were reported throughout the study

What This Means:

This study demonstrates that collagen peptide supplementation can produce visible improvements in skin quality, particularly in reducing wrinkles associated with aging. The findings support the role of collagen peptides as a functional ingredient that works from within to improve skin structure, complementing topical skincare approaches.

Human Bioavailability Study (Hydroxyproline Peptides in Blood)

Published in Journal of Agricultural and Food Chemistry, 2007.

Study Type: Single-blind, crossover human clinical trial

This study investigated how oral collagen peptide ingestion affects the presence of bioactive peptides in human blood, providing insight into whether collagen is absorbed and utilized by the body after consumption.

Key Findings:

  • Collagen peptides were detected in the bloodstream as intact di- and tripeptides, not just broken-down amino acids
  • Approximately 30% of circulating hydroxyproline was present in peptide form, indicating meaningful systemic absorption
  • Prolyl-hydroxyproline (Pro-Hyp) was identified as a major circulating peptide with known biological activity in skin cells
  • Collagen derived from marine sources showed higher bioavailability compared to porcine sources
  • Peptides appeared in circulation within hours of ingestion and remained detectable over time

What This Means:

Collagen peptides are not simply digested and lost, they are absorbed into the bloodstream as bioactive compounds that can interact with the body’s tissues. This supports the mechanism behind collagen supplementation, showing how it can deliver functional peptides that may contribute to skin health from within.

Collagen Peptide Supplementation & Skin Health

Published in ITE Letters on Batteries, New Technologies & Medicine, 2006.

Study Type: Open-label human clinical study

This study evaluated the effects of daily oral collagen peptide supplementation on skin properties, including hydration, elasticity, and surface structure in adult women.

Key Findings:

  • Collagen peptide ingestion led to improvements in skin elasticity and viscoelastic properties
  • Skin hydration levels increased, particularly in areas prone to dryness
  • Participants showed reduced skin roughness and improved surface smoothness
  • Sebum production and overall skin condition showed measurable improvement
  • No adverse effects were reported during the study period

What This Means:

This study provides clinical evidence that collagen peptides can improve key markers of skin quality in humans, including hydration and elasticity. These changes are directly associated with healthier, more resilient skin and support the role of collagen supplementation as a functional, ingestible approach to skin health.

Bioavailability of Collagen Peptides in Humans

Published in Journal of Agricultural and Food Chemistry, 2005.

Study Type: Human absorption and pharmacokinetic study

This study investigated how collagen peptides are digested, absorbed, and circulated in the human body following oral ingestion.

Key Findings:

  • Collagen peptide ingestion led to the appearance of intact dipeptides (especially Pro-Hyp) in human blood
  • Peak plasma levels occurred approximately 1–2 hours after ingestion
  • Measurable concentrations of bioactive peptides reached 20–60 nmol/mL in circulation
  • These peptides remained detectable for several hours, indicating systemic availability
  • The presence of these peptides confirms that collagen is not fully broken down into free amino acids, but absorbed in functional peptide form

What This Means:

This study provides direct human evidence that collagen peptides are absorbed into the bloodstream as bioactive compounds, not just basic protein. These circulating peptides can act as signaling molecules, supporting downstream biological processes such as fibroblast activation and extracellular matrix remodeling, key mechanisms involved in maintaining skin structure and elasticity.